Mucositis severity and duration in patients treated with CT depend on antineoplastic agents, treatment, combinations, dosages and number of cycles
Lesions are seen mostly on the movable mucosae of the buccal mucosae and lateral and ventral surfaces of the tongue. The hard palate and gingiva appear not susceptible to CT-induced mucositis
The early clinical sign of mucositis is erythema, presenting about 4-5 days following CT infusion; 7 to 10 days after CT, ulcers develop, often requiring opioid intervention
CT-induced mucositis last approximately 1 week and generally heals spontaneously by 21 days after infusion
Neutropenia caused by high dose CT, can predispose the bacteraemia, septicaemia and fungaemia, which may even be life threatening.